Population Pharmacokinetic - Pharmacodynamic Analysis of Anidulafungin in Adult Patients with 1 Fungal Infections
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چکیده
Population Pharmacokinetic-Pharmacodynamic Analysis of Anidulafungin in Adult Patients with 1 Fungal Infections 2 Ping Liu 3 4 Clinical Pharmacology, Specialty Care, Pfizer Inc, Groton, CT, USA 5 6 7 Running title: Population PK-PD analysis of anidulafungin 8
منابع مشابه
Population pharmacokinetic-pharmacodynamic analysis of anidulafungin in adult patients with fungal infections.
To evaluate the exposure-response relationships for efficacy and safety of intravenous anidulafungin in adult patients with fungal infections, a population pharmacokinetic-pharmacodynamic (PK-PD) analysis was performed with data from 262 patients in four phase 2/3 studies. The plasma concentration data were fitted with a previously developed population PK model. Anidulafungin exposures in patie...
متن کاملPopulation Pharmacokinetic - Pharmacodynamic Analysis of Voriconazole and Anidulafungin in 1 Adult Patients with Invasive
Population Pharmacokinetic-Pharmacodynamic Analysis of Voriconazole and Anidulafungin in 1 Adult Patients with Invasive Aspergillosis 2 Ping Liu and Diane R. Mould 3 4 Clinical Pharmacology, Global Established Pharma Business, Pfizer Inc., Groton, CT, USA 5 Projections Research Inc., Phoenixville, PA, USA 6 7 8 Running title: Population PK-PD analysis of voriconazole and anidulafungin in IA pat...
متن کاملAnidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasis.
Candidemia is often fatal, especially in patients with persistent neutropenia. New therapies are needed. We performed 24-h pharmacodynamic studies to compare the efficacies of anidulafungin, fluconazole, and amphotericin B in neutropenic mice with disseminated candidiasis caused by one of three strains of Candida glabrata. Anidulafungin produced a maximal fungal kill (E(max)) of 1.4 to 1.9 log(...
متن کاملSafety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infections.
Anidulafungin is an echinocandin with activity against Candida species and Aspergillus species. Adult dosages under study are 50 mg/day for esophageal candidiasis and 100 mg/day for invasive candidiasis and aspergillosis. Little is known, however, about the safety and pharmacokinetics of anidulafungin in children. A multicenter, ascending-dosage study of neutropenic pediatric patients was there...
متن کاملAnidulafungin in the treatment of invasive fungal infections
More antifungal agents have reached clinical use in the past two decades than at any other time. The echinocandins have been a welcome addition to this group, with the latest being anidulafungin. There are several lines of evidence to support anidulafungin's role as primary therapy for the treatment of invasive candidiasis in non-neutropenic patients, and as alternative therapy to fluconazole i...
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تاریخ انتشار 2012